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Vesikulär stomatit-virus tillhör genus Vesiculovirus inom familjen Rhabdoviridae. Det delas upp i fyra typer: New Jersey, Alagoas, Cocal och Indiana. New Jersey är vanligast förekommande. Viruset korsreagerar i serologiska tester med andra vesikulovirus. Vesikulär stomatitvirus kan överleva långa perioder i kyla, men avdödas med formalin eller upphettning.
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